Background: Extensive dermatophytic infections and infections of hair and nails which affect the quality of life of people are treated with systemic anti fungals. The present study compared topical sertaconazole and topical terbinafine in management of dematophytoses. Materials & Methods: 92 patients having dematophytoses of both genders were divided into 2 groups of 46 each. Group I patients were given topical sertoconazole two times daily and group II patients were given topical terbinafine two times daily. Patients were assessed for erythema, scaling, and pruritus. Results: There were 26 males and 20 females in group I patients and 24 males and 22 females in group II. Tinea corporis was seen in 24 in group I and 18 in group II and Tinea cruris 22 in group I and 28 in group II. Erythema grade 1 was seen in 12 in group I and 11 in group II, scaling grade 0 was seen in 11 in group I and 12 in group II, pruritis grade 1 in 14 in group I and 16 in group II. The difference was non- significant (P> 0.05). Conclusion: Authors found that both drugs found to be equally effective in management of cases of Tinea corporis and Tinea cruris.