Background: The readmission rate following hospitalization for chronic obstructive pulmonary disease (COPD) exacerbations is extremely high and has become a common and challenging clinical problem in developing countries. Aim: To compare clinical, radiographic, and laboratory characteristics of acute exacerbation of COPD patients among admission and re-admission group. Materials and methods:140 patients with AECOPD were recruited in admission group and 50 in re-admission group. Hemodynamic parameters (respiratory rate, SPo2, Heart rate, blood pressure), radiological findings (2D ECHO and chest x-ray), blood investigation (total leucocyte count & hemoglobin concentration), and sputum gram staining findings were analysed and compared in both the groups Results: Among re-admission group, suggestive of respiratory acidosis was 72% and tachycardia were 66% respectively. Dyspnea and Tachypnea were significantly higher in re-admission group as compared to admission group (p<0.05).Prevalence of left heart failure was 20% and suggestive of PAH was 26% in readmission group (p>0.05). Pneumonitis and neumothorax was more among re-admission group. Leukocytosis was 58%, polycythemia was 10% and anemia was 14% in readmission group, not significantly differ from admission group (p>0.05) Conclusion: Addressing risk factors, supporting patient education and maximizing treatment compliance are the key elements for minimizing re-admission rates in AECOPD patients