Background: Solitary thyroid nodules are a common clinical condition, particularly among women, and pose a significant risk due to the potential for malignancy. Accurate diagnosis and management are crucial in reducing the morbidity associated with thyroid disorders.Objective: The study aimed to evaluate the incidence, clinical presentation, and histopathological correlation of solitary thyroid nodules in patients treated at a tertiary care center.Methods: This prospective study was conducted at the SS Institute of Medical Sciences and Research Centre, Davangere, India. Fifty patients with clinically diagnosed solitary thyroid nodules who underwent surgery were included. Clinical examination, fine needle aspiration cytology (FNAC), and histopathological evaluation were performed to determine the nature of the nodules.Results: The study population consisted of 84% females and 16% males, with a female-to-male ratio of 5.25:1. The majority of patients were in the 31-40 age group. FNAC revealed that 60% of the nodules were colloid nodular goitre, followed by 10% follicular neoplasm. Histopathological examination confirmed that 88% of the nodules were benign and 12% were malignant. The most common benign diagnosis was colloid nodular goitre (56%), while the most common malignancy was follicular carcinoma (6%).Conclusion: Solitary thyroid nodules are more frequent in females, with a higher risk of malignancy observed in males. FNAC is a valuable tool for preoperative assessment, but histopathological analysis remains essential for definitive diagnosis. Early diagnosis and appropriate management are critical in preventing the progression of malignant nodules.