Background: The longevity of dental restorations depends on mechanical performance, yet cyclic fatigue—a key cause of failure—remains underexplored, particularly for new materials like Zirconomer and short fiber-reinforced composites.Objective: This study evaluates and compares the compressive fatigue limits of short fiber composite, resin-modified glass ionomer cement (RM GIC), Zirconomer, and Amalgam to assess their long-term durability.Materials and Methods: A total of 30 cylindrical specimens for each material were prepared. Compressive strength (n=10) and compressive fatigue limit (n=20) were assessed using a universal testing machine. The staircase method determined the compressive fatigue limit, with cyclic loading conducted at a frequency of 10 Hz for up to 5000 cycles.Results: Significant differences were observed in the compressive strength and fatigue limits among the materials (p < 0.001). Short fiber composite and Amalgam demonstrated the highest compressive strength and fatigue limits, while Zirconomer and RM GIC showed comparatively lower values. The compressive fatigue limit as a percentage of compressive strength was highest for RM GIC (69.81%) and lowest for Zirconomer (64.73%).Conclusion: Short fiber composite and Amalgam showed superior fatigue resistance, indicating greater clinical longevity, while Zirconomer exhibited lower resistance. All materials experienced reduced compressive strength after cyclic loading, emphasizing the need for fatigue evaluation to predict long-term success.