Background: One of the most used regional anesthetic methods for lower limb and lower abdomen procedures is epidural anesthesia. The present study compared 0.75% intrathecal isobaric ropivacaine plus dexmedetomidine and 0.75% isobaric ropivacaine plus clonidine for lower limb surgeries. Materials & Methods: 110 patients undergoing lower limb surgeries under intrathecal anesthesiawere divided into groups of 55 each. Group I patients received isobaric ropivacaine 0.75% 15 mg + 30 mcg clonidine and group II patients received isobaric ropivacaine 0.75% 15 mg + 10 mcg dexmedetomidine. Parameters such as sensory blockade, motor blockage, VAS and analgesia was recorded. Results: The group I had 25 males and 30 females and group II had 28 males and 27 females. The mean duration of surgery was 108.1 minutes in group I and 114.5 minutes in group II. The mean time to onset of sensory analgesia was 8.4 minutes in group I and 5.2 minutes in group II. The time taken for regression of sensory block to t12 was 155.2 minutes in group I and 202.7 minutes in group II. The mean time to first postoperative analgesic requirement was 270.4 minutes in group I and 360.4 minutes in group II. The mean time taken to achieve complete motor blockade was 14.1 minutes in group I and 13.6 minutes in group II. The difference was significant (P< 0.05). The mean VAS in group I was 4.5 and in group II was 3.1. The difference was significant (P< 0.05). Conclusion: For patients undergoing intrathecal anesthesia, dexmedetomidine combined with ropivacaine demonstrated earlier sensory blockage and longer durations of both sensory and motor blockade for lower limb procedures.