Background: Androgenetic alopecia (AGA) is a common condition affecting self-image and psychological well-being. Current treatments provide partial hair regrowth, leading to exploration of alternative therapies like platelet-rich plasma (PRP). Objectives: To evaluate the efficacy of PRP therapy in patients with AGA. Materials and Method: This prospective, comparative, cross-sectional study included 100 male patients with AGA, divided into two groups (PRP + topical minoxidil + oral dutasteride, and topical minoxidil + oral dutasteride). PRP injections were administered at 4-week intervals for 3 months. Results: Elevated oxidative stress (MDA) was found in 31% of patients, and mean DHT levels were 7.85 nmol/ml (Grade I-III) and 27.89 nmol/ml (Grade IV-VI). Tricoscopic findings revealed yellow spots and miniaturization.After 3 months, 87% of patients showed improvement in hair loss grade, with better results in the PRP group. Patient satisfaction scores were higher in the PRP group, with a mean grade reduction of 1.03 compared to 0.85 in the non-PRP group. Most patients (84%) reported no adverse effects, with temporary pain being the most common side effect in the PRP group. Dermoscopy findings revealed yellow spots and miniaturization. Conclusion: PRP therapy, combined with minoxidil and dutasteride, is a safe and effective treatment for AGA, promoting hair regrowth and reducing hair loss.