Background:Organo Phosphorus Poisoning is very common in India, especially in rural area. It is a common pesticide used in the fields by Farmers. Accidental poisoning is also common with organo phosphorus pesticides while spraying in the fields. The first organophosphate insecticide was created in the mid 1800’s. Organo phosphates are used as medications, Insecticide, Nerve gas agents as a weapon in the chemical war. Aim of the Study:To know the different clinical features and management of organophosphorus poisoning in a teaching hospital.Materials and Methods: This study has been conducted for 6 months from April 2022 to September 2022 in the department of General Medicine in GERMS Medical college, Junagadh.Results: We have examined total number of 260 patients. In our study, out of these 260. 118 are females and 142 are males 21 patients were died because of complications.Conclusion:Three facets of approach to the symptoms and signs in OP poisoning have been presented. Although all OP compounds are generally considered within a single group entity, it is recognized that di‑methyl and diethyl OP poisoning have different outcomes.