Background: The association between menstrual cycle irregularities and system disease has been evaluated in previous studies. However, the association between BMI, periodontal disease and menstrual cycle irregularity has not been fully investigated. Aim: Evaluation of the Association between menstrual irregularities and periodontal diseases. Material and methods: A total of 100 female participants were included in the present study. The collection of data pertaining to reproductive factors involved the participants' recollection of the duration of their menstrual cycle, as well as their history of hormone replacement therapy and oral contraceptive use. The participants' body weight and height were measured with a precision of 0.1 kg and 0.1 cm, respectively. The assessment of periodontal disease was conducted utilizing the community periodontal index (CPI) established by the World Health Organization (WHO). Periodontal disease was classified as present when the Community Periodontal Index (CPI) had a value of 3 or higher. Results: The impact of body mass index (BMI) or waist circumference on the occurrence of menstrual cycle irregularity and periodontal diseases. The occurrence of irregular menstrual cycles was found to be more common among individuals with higher body mass index or waist circumference (P values for trend were 0.02 and 0.26, respectively). The prevalence of periodontal disease was found to be higher in individuals with a higher body mass index or waist circumference, as indicated by a statistically significant P-value for trend of less than 0.001. Adjusted odds ratios and their 95% confidence intervals of the individuals with periodontal diseases were 1.71 (1.15, 2.99) after adjustment with age and 1.83 (1.15, 3.22) for BMI. Conclusion: The study revealed that irregularities in the menstrual cycle among premenopausal Indian women may serve as a potential indicator of increased susceptibility to periodontal diseases. Keywords: Menstrual irregularities, Periodontal diseases.