Background: Perinatal asphyxia is one of the common neonatal problems leading to neonatal morbidity and mortality. Globally, hypoxia of the newborn (birth asphyxia) or the fetus (fresh stillbirth) is estimated to be around 23% of 4 million neonatal deaths and 26% of the 3.2 million stillbirths each year(1). In India, approximately 2,50,000 to 3,50,000 infants death occur every year due to birth asphyxia, mostly within the first three days of life. In this study by estimating Renal functions, Serum Electrolytes, Serum Total calcium and Echocardiographic measurement of Ejection fraction and Degree of Pulmonary Hypertension in asphyxiated term newborns, we may able to initiate appropriate treatment at the earliest and helps in improving their neurodevelopmental outcome and preventing mortality Aims and Objectives  To Study the Clinical and Biochemical abnormalities in perinatal asphyxia in term newborns  To Evaluate the Cardiac abnormalities in perinatal asphyxia in term newborns  To Correlate the Clinical, Biochemical and Cardiac abnormalities with severity of HIE Methodology:The study was approved by Ethical committee of Chengalpattu Medical college and Hospital. 129 neonates who are admitted in view of perinatal asphyxia in SNCU of Villupuram Medical college and Hospital as per predefined criteria are recruited into the Study after getting informed written consent from the parents. Conclusion: It can be concluded from the study that babies born with moderate asphyxia had clinical features like seizures and respiratory distress in most of the cases where as babies with severe asphyxia had severe presentation in the form of Refractory seizures, shock, oliguria and feed intolerance. Asphyxiated babies had developed elevated blood urea, serum creatinine levels along with lower serum sodium and total calcium levels in proportion to the severity of asphyxia. Babies with severe birth asphyxia had decreased ejection fraction indicating significant myocardial dysfunction and increased risk of developing pulmonary hypertension within 24 hours of birth.