SARS-CoV-2 viral disease is transmitted primarily by release of respiratory droplets from infected persons in asymptomaticor symptomatic stages of illness.1COVID-19 has wide-ranging presentations with the hazard of adverse outcomes such as respiratory failure and sepsis.1 Radiological findings of COVID-19 pneumonia on high-resolution computed tomography (HRCT) include peripherally placed ground glass opacities with or without consolidation.2 These imaging features overlap with radiologic signs of autoimmune illnesses that afflict the lungs. Considering that 596,873,121 cases of COVID-19 infection were reported in 2022, diagnostic challenges in discerning the viral ailment from relatively rarer autoimmune conditions has resulted in misdiagnosis, missed diagnosis and delayed diagnosis, with consequential deleterious sequels of co-occurring conditions such as irreversible end-organ damage.3,4 This case report is concerned with distinguishing undiagnosed GPA from co-occurring COVID-19 infection to underscore the importance of discriminating conditions with similar radiologic presentations to promptly shrink the risk of unabated activation of autoimmune mechanisms.