A frequent condition that might affect people at some time in their lives is non-specific neck pain. Without a clear-cut origin or underlying illness, it is characterised by neck-region discomfort and pain. Magnesium is an essential mineral that is essential for many physiological processes in the body, including pain management. Magnesium also demonstrates significant characteristics that can affect how pain is perceived and offer relief from some types of pain. This study's objective is to compare the effects of magnesium supplementation and exercise to exercise alone in those with non-specific neck pain. Method: 30 subjects with non-specific neck pain were randomly divided into 2 groups, experimental and conventional group (n=15). The control group received conventional therapy i.e. exercises like chin tuck, static strengthening exercises, as opposed to the experimental group who had a chin tuck, static exercises, and transdermal magnesium oil application. Pre- and post-intervention assessments of all outcome measures, including VAS, NDI, and magnesium RBC levels, were done using statistical analysis. Result: The experimental group demonstrated particularly notable gains in VAS and magnesium RBC levels, whereas the control group experienced improvements in functional outcomes, most notably NDI, in both groups. Both groups displayed significant improvement. This evidence suggests that combining magnesium with exercise is more beneficial for treating people with non-specific neck discomfort than exercising alone.