Background & Objectives: Rheumatoid arthritis is a chronic systemic inflammatory disorder with an unknown etiology that mainly involves a synovial joint. Cardiovascular disease is one of the more common complications in patients with rheumatoid arthritis (RA). Therefore, the present study was planned to evaluate RA patients in terms of clinical features, socio-demographic characteristics, behavioral traits, anthropometric measurements, traditional cardiovascular risk factors history, clinical examination, lipid profile, and inflammatory biochemical markers- (hs-CRP, Hcys, ESR) and MDA. Methods: In this observational case-control study, 150 confirmed cases of rheumatoid arthritis, and 150 age and sex-matched controls were included. Both rheumatoid arthritis subjects and healthy individuals were thoroughly investigated for traditional cardiovascular risk factors, oxidative stress, lipid levels, and inflammation. Results: The mean levels of smoking habit, physical activity, BMI, WHR, SBP, RA factor, RA duration, and ESR, lipid profile, hs-CRP, Hcys and MDA showed a statistically significant difference (P<0.05) between the two groups. RA subjects were associated with an increase in level of these parameters as compared to the control group. Conclusion: The levels of traditional cardiovascular risk factors, oxidative stress lipid levels, and inflammatory markers were statistically higher in rheumatoid arthritis compared to the control group. Therefore, patients with rheumatoid arthritis have to be screened for further complications in order to identify them earlier and to provide early treatment.