Introduction: The purpose of this study is to evaluate and compare the fracture resistance of cobalt chromium four unit fixed dental prosthesis framework obtained by CAD/CAM milling, 3D printed resin pattern casting and direct metal laser sintering (DMLS). The null hypothesis was that no differences would be found in fracture resistance of cobalt chromium four unit fixed dental prosthesis framework obtained by CAD/ CAM milling, 3D printed resin pattern casting and direct metal laser sintering (DMLS). Material and methods: A total number 30 patients were selected and they are further divided into three groups as follows. 10 copings of CAD/CAM Milling. 10 copings of 3D Printed Resin Pattern Casting. 10 copings of Direct Metal Laser Sintering (DMLS). Results: The results only showed a difference in fracture resistance between the CAD/CAM and the DMLS-group (p < 0.05). Despite the fact that there was a lot of variation in the readings of resin pattern casting. Its mean fracture resistance was 6298.5, which was higher than the other two groups (CAD/CAM Milling and DMLS). The average of the fracture load came of resin pattern casting was in comparison with CAD/CAM Milling (6247.2) and higher than that of DMLS (5153.0). Conclusion: There is a lot of variations in the values of 3 D Printed Resin Pattern Casting, hence it does not have statistically significant difference in fracture resistance. Hence, the fracture resistance amongst all the groups was exhibited in the following order: a) CAD/CAM Milling b)Direct Metal Laser Sintering (DMLS). The fracture resistance for CAD/CAM Milling was better than all the other groups.