Background: Tuberculosis (TB) is a contagious bacterial infection caused by Mycobacterium tuberculosis. The present study was conducted to assess tuberculous lesion in association with diabetes mellitus patients. Materials & Methods: 120 cases of respiratory diseases of both genders were selected. Group I patients had both tuberculosis with DM and group II patients were diagnosed with tuberculosis only. All were subjected to examinations such as chest x-rays, sputum examination for acid fast bacilli, bronchoscopy, etc. Assessment of diabetes mellitus was done following fasting blood glucose, random blood glucose and glycated hemoglobin level. Results: Out of 120 patients, males were 76 and females were 44. Age group 11-20 years had 2 and 5, 21-30 years had 8 and 9, 31-40 years had 5 and 12, 41-50 years had 8 and 13 and >50 years had 15 and 21 patients in group I and II respectively. The difference was significant (P< 0.05). Radiological findings in group I and group II patients was cavitatory lesions in 3 and 7, infiltrative lesions in 12 and 24, exudative lesions in 6 and 10 and pleural effusion in 2 and 5 patients respectively. The difference was significant (P< 0.05). Conclusion: Early identification of diabetes mellitus in people with tuberculosis is likely to boost its detection. This will enable early detection of the coexistence of these two illnesses, allowing for the simultaneous application of the necessary treatments.