Aim: To assess the prevalence of PCSs after open and laparoscopic cholecystectomy. Material and Methods: Patient’s admitted through surgery outpatient department / Emergency / transferred from other departments for gallstone disease was taken for the study after clearance from institutional ethical committee.A correlation matrix was developed to see the postcholecystectomy syndrome in patients who have under gone open cholecystectomy or laparoscopic cholecystectomy. In order to maintain the similarity, all the patients included in the study were catheterized and Ryle’s tube drainage was given during the intra operative period and these were removed with in next 48 hours according to the patient’s condition. Results: Total 154 were recruited during the study period, out of which 38 and 116 underwent open and laparoscopic cholecystectomy respectively.Post- op pain (hours), duration of hospital stay (days) and return to work (days) was significantly more in open as compared to laparoscopic cholecystectomy with statistically significant difference as p<0.05. Incidence of PCS was reported among 7.89% of the subjects in open and laparoscopic cholecystectomy while 18.19% of the subjects in laparoscopic cholecystectomy. Hence incidence of PCS was more in laparoscopic as compared to open cholecystectomy with statistically significant difference as p<0.05. Conclusion: Although incidence of PCS was more in laparoscopic as compared to open cholecystectomy, still it is safe and efficacious in thehands of experienced surgeons. There is a definitive learningcurve for surgeons and complications rate reduces assurgeons become more and more familiar with thisprocedure.