Background: Systemic disorders and xerogenic medications are common causes of salivary gland hypofunction. The present study was conducted to assess the effect of complete denture wear on the flow rate of saliva in both medicated and apparently healthy patients. Materials & Methods: 50 patients requiring complete denture of both genders were divided into 2 groups of 25 each. Group I was medicated group and group II was unmedicated group. Unstimulated whole saliva was collected and was then determined volumetrically and the flow rate was calculated before denture insertion, 24 hours after denture insertion, and 3 months after denture insertion based on the sample collection time and was expressed in ml/minute. Results: Group I had 14 males and 11 females and group II had 12 males and 13 females. The mean salivary flow rate before denture insertion in group I was 0.24 ml/min, 24 hours after denture insertion was 0.36 ml/min and 3 months after denture insertion was 0.27 ml/min. In group II, mean salivary flow rate before denture insertion was 0.29 ml/min, 24 hours after denture insertion was 0.38 ml/min and 3 months after denture insertion was 0.28 ml/min. The difference was significant (P< 0.05). Conclusion: There was no difference in salivary flow rate in in both medicated and apparently healthy patients before and after insertion of denture.