Coronary artery disease (CAD) may be caused by or cause of oxidative stress. In the present study the predictive values for oxidative stress, oxidant stress, oxidant status and antioxidant status were investigated in coronary artery disease (CAD) patients (n = 31) and in healthy ageand sex- matched controls (n = 19). Malondialdehyde (MDA) and total oxidant status levels were measured as markers of oxidative stress while total antioxidant status was determined to assess the antioxidant protection in their blood-sera samples. Lipid profiling was also carried out for each individual. The MDA, total cholesterol, triglycerides, low density lipoproteins, very low density lipoproteins and total oxidant levels were found significantly higher though HDL-cholesterol levels were significantly decreased in the patients. The significant (p < 0.000) increase in lipid peroxidation (MDA) and oxidant status and a significant (p < 0.000) decrease in HDL-cholesterol and antioxidant status implies an imbalance of the oxidant: antioxidant status in CAD patients as indicated by the significantly raised oxidative stress index and requires rectification to prevent other co-morbidities.