Aim: The aim of the present study was to assess the impact of the prophylactic use of antibiotic coated intramedullary nail in treatment of open tibia fractures.Methods: This prospective study was conducted in the Department of Orthopedics. 50 patients were treated over a period of 16 months with gentamicin coated tibia interlocking nail after taking written and informed consent.Results: All 50 patients (36 males and 14 females) were followed up for minimum of six months duration. This study comprised of 50 patients, out of them 25 patients had grade-I, 20 patients had grade-II and 5 patients had grade-III compounding. Time taken in wound healing in majority of patients was less than 5 weeks (46%). Majority of patents (48%) had RUST score 8 at six months of duration. Large numbers of patients had fair outcome 40%.Conclusion: Implant related infection pose an important challenge in the surgical treatment of tibia shaft fracture. Local administration of antibiotics might minimize the risk of infection. In this study we showed that use of antibiotic coated nail to treat open tibial fracture was associated with an absence of deep wound infections.