Background: The most important use of EBUS technique is in the nodal staging of patients with non-small cell lung carcinoma (NSCLC).The present study was conducted to compare and asses the effect of dexmedetomidine and propofol with propofol alone when given in endobronchial ultrasound guided needle aspiration (EBUS) procedure. Materials & Methods: A total of 30 patients aged between 40-80 years scheduled for endobronchial ultrasound guided needle aspiration surgeries were divided into two groups by alternative method: Group DP = received i.v. Dexmedetomidine 1mcg/kg with i.v. propofol 0.5mg/kg and Group P = received i.v. propofol 1mg/kg (additional doses of 10-20 mg given until the Sedation Scale score reached 2-4 in both the groups). Results: No significant difference was reported in mean age (61.12±5.56 vs. 62.64±4.34 years), duration of disease (41.40±5.30 vs. 41.20±5.26 years), weight (52.60±5.96 vs. 52.32±4.02 kgs), BMI (21.36±4.80 vs. 21.20±5.48 kg/m2), pulse rate (102.32±9.45 vs. 95.68±2.79), mean arterial pressure (66.22±3.17 vs. 65.20±3.71; p=0.543), SPO2 (95.21±1.63 vs. 94.14±1.43; p=0.423) and respiratory rate (21.68±4.11 vs. 20.78±3.84; p=0.544) between Group DP and Group D respectively. No significant difference was obtained in terms of mean frequency of gag reflex between both the groups as revealed by the insignificant p value of 0.684. No significant difference was obtained in terms of intra-operative frequency of decrease in SPO2 between both the groups as revealed by the insignificant p value of 0.821. No significant difference was obtained in terms of rescue bolus requirement between both the groups as revealed by the insignificant p value of 0.411. A significant difference was obtained in terms of Ramsay sedation scale between both the groups postoperatively as revealed by the significant p value of 0.03. Conclusion: Although, patients undergoing EBUS procedure showed increased frequency of gag reflex and additional requirement of propofol doses in dexmedetomidine group, they showed less frequency of dip in saturation or hypoxia as compared to propofol group and were more comfortable postoperatively.