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Volume 12 Issue 2 ( April- June) 2023

Original Articles

Correlation of fibrinogen level with lipid profile in type 2 diabetes mellitus: A observational study
Dr. Parul Nema, Dr. Vivek Kumar Jain, Dr. Shammi Kumar Jain, Dr. Vishnu Gupta

Background: Increasing evidence from epidemiological studies suggest that elevated plasma fibrinogen levels are associated with an increased risk of cardiovascular disorders especially in diabetic patients. Objective was to correlate fibrinogen levels in patients of type-2 diabetes mellitus with lipid profile.Methods:It is a descriptive observational study conducted among type-2 diabetes mellitus patients in a tertiary care teaching hospital, central India. Newly detected type-2 diabetic patients with and without associated hypertension of more than 40 years of age belonging to both sexes were included. All data were analyzed statistically.Result: Total 104 patients were involved in our study. Of which 75 were males and 29 females. There was a significant positive correlation between plasma cholesterol level and plasma fibrinogen level. The patients who had serum triglyceride level between 100-149 mg/dL had plasma fibrinogen level about 4.19±0.1 g/L and those with serum triglyceride level more than 400 mg/dL < had 9.01±0.83 g/L plasma fibrinogen level. Significant positive correlation between serum triglyceride level and plasma fibrinogen level found. 36 patients with HDL level 35-39 mg/dL had plasma fibrinogen level of 5.9±1.50 g/L. So, there was a significant negative correlation between serum HDL and plasma fibrinogen level.Conclusion: The present study showed positive correlation between serum cholesterol level, LDL level and triglyceride level with plasma fibrinogen levels. There was inverse relation with HDL level.

 
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