Background: To compare c- reactive protein levels in patients with periodontal disease. Materials & methods: A total of 30 systemically healthy subjects were divided into two groups: Group I, non-periodontitis subjects and group II, chronic generalized periodontitis patients. The results were analysed using SPSS software. The p – value less than 0.05 was considered significant. Results: A total of 30 subjects were included. CRP values of the two groups were significantly different from each other, with CRP levels in the group II greater than those in the group I subjects. Conclusion: Increase in serum CRP levels in subjects with generalized periodontitis.