Hundreds of thousands of patients undergo joint replacement surgeries each year,worldwide and millions of people have anindwelling prosthetic articulation. Prosthetic jointinfections (PJIs) are devastating complications which follow each surgery. The isolates were identified by colony morphology, Gram’s stain and biochemicalreactions and antibiotic susceptibility tests performed by CLSIrecommended by Kirby-Bauerdisc diffusion method. Out of 77 clinically suspected cases of Orthopaedic infected implant, 70 cases showed positiveculture and 7 cases were culture negative. Among 70 isolates, most common wasStaphylococcus aureus 32 (45.71%), followed by Proteus mirabilis 8(11.42%), CONS 07(10%), E.coliand Pseudomonas aeruginosa 06 each (8.57%),(5.43%), Klebsiellasppand Citrobacterspp 04 each (5.71%) and Streptococcus spp 03 (4.28%)Staphylococcus aureus was the predominant pathogen isolated from the Orthopaedicimplant infections from our hospital.