Background: WHO has estimated that 600 million people worldwide have COPD. Additionally, exacerbations lead to indirect costs because of days lost from work. COPD affects 30% of patients seen in chest clinics and constitutes 1-25% of hospital admissions all over India. Objectives: To identify and establish bacteriological profile of elderly patients with acute exacerbation of chronic obstructive pulmonary disease admitted to VIJAYANAGARA INSTITUTE OF MEDICAL SCIENCES, BALLARI.Methods:This is descriptive observational study conducted amongst diagnosed cases of AECOPD approached to department of Medicine VIJAYANAGARA INSTITUTE OF MEDICAL SCIENCES BALLARI during the period from JANUARY 2020 to JANUARY 2021.Result:Out of 131 AECOPD patients, majority of the patients were from 60-70 years i.e., 92(70.2%) Mean age of the study population was 69.42±812.5 years. Males were 92(70.2%) and females were 39(29.8%). Klebsiella pneumonia was most commonly isolated organism in our study with the prevalence of 24.4%, followed by Commensals (18.3%), Pseudomonas species (13%), E coli (12.2%).Conclusion:Breathlessness and cough was complained by all 131 AECOPD patients i.e., 100%. Klebsiella pneumonia was most commonly isolated organism in our study with the prevalence of 24.4%, followed by commensals (18.3%), pseudomonas species (13%), E. coli (12.2%).