Participants were women with no risk for breast cancer who presented for routine mammography and provided written informed consent. Each participant underwent mammography followed by ultrasound, both studies performed by the same Radiologist. 460 women underwent screening mammogram and adjunct ultrasounds were examined. 18 patients underwent tissue biopsies and histopathological correlation. Women had both ultrasound and mammography were part of the study. For the detection of all breast pathologies, the addition of ultrasound to mammography produced a statistically higher sensitivity with an improvement in sensitivity by 50%. However, this increased sensitivity is accompanied by a drop in specificity by 5%.