Background: To assess the incidence and outcome of acute lung injury in patients with traumatic brain injury.Materials& Methods: A total of 200 patients with presence of traumatic brain injury were enrolled. Complete demographic and clinical details of all the patients was obtained. Emergency care was done and radiographic analysis of all the patients was done. CT and MRI findings were separately recorded. Chest radiographs were carried out. Assessment of incidence of acute lung injury was done. Results: Out of 200 patients, acute lung injury was seen in 20.5 percent of the patients. Out of 41 patients with presence of acute lung injury, mean hospital stay was 16.2 days while good neurological outcome was seen in 18.29 percent of the patients. Overall mortality was seen in 19.77 percent of the patients. Conclusion: The mechanism of TBI-associated acute lung injury is multifactorial. Hence, adequate screening of pulmonary functions with prompt treatment should be done.