Developing countries, particularly in South Asia, have a high prevalence of oral cancer, accounting for approximately 50% of cases worldwide. This trend is attributed to a group of conditions known as "oral potentially malignant disorders" (OPMD), which comprises of oral hypoplasia, dysplasia, leukoplakia, erythroplakia, and oral submucousfibrosis.Tobacco usage and alcohol consumption are the primary causes of more than 90% of oral cancer cases. Moreover, some genetic factors, including the ABO blood group, have also been hypothesized to be linked to the development of different forms of cancer. Several studies have explored the possible association between ABO blood type and oral cancer, as well as other conditions that could potentially lead to cancer. However, the results of these studies have been inconsistent and inconclusive. As a result, it has not been established as a confirmed risk factor. The suggested theory linking blood group A with carcinomas postulates that the cancerous cells may generate an antigen that shares certain immunological features with blood group A.People who have blood types A and AB lack antibodies for A, which can render them more vulnerable to developing carcinomas. Several studies have explored the possible association between ABO blood type and oral cancer, oral submucous fibrosis, and other related conditions that have the potential to become malignant.The aim and objective of this study is to investigate the relationship between ABO blood group types and oral cancer, oral potentially malignant disorders (OPMD), and oral submucous fibrosis (OSMF) in greater detail.