Objectives: The present study was undertaken to study the validity of pipelle endometrial sampling for identifying endometrial lesions in patients with abnormal uterine bleeding. This study seeks to place D&C in its historical perspective and considers D&C as gold standard and to chart the efficacy of Pipelle for sampling the endometrial lining of the uterus. Patients and Methods: A cross-sectional study was done at Shri B M Patil Medical College, Hospital &RC Vijayapura.100 cases of abnormal uterine bleeding attending the OPD in the department of obstetrics and gynaecology were included in the study. The endometrial sample was obtained with Pipelle sampler in Out Patient Department followed by formal D&C and sent for histopathology assessment. Samples were labelled as A and B and sent to a histopathologist who was blinded as to the method of sampling. The histopathology reports of both samples were compared. Results: Pipelle had a sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy of 100% in diagnosing proliferative phase and endometrial carcinoma. Pipelle also had a high predictive value and accuracy for diagnosing Secretory phase, Hyperplasia and Hyperplasia with atypia. The Histopathology results obtained by D&C and pipelle sampling were comparable. No opinion could be inferred in 5 cases in pipelle group and 4 cases in D&C group due to inadequate sample. Conclusion: Endometrial tissue obtained by pipelle has shown high sensitivity and specificity in patients with abnormal uterine bleeding even for hyperplasia and malignancy. Thus pipelle can be considered as a first line investigation for getting adequate endometrial sample in patients with abnormal uterine bleeding.