Background: The Covid-19 spread and outburst since December, 2019 and has lead to many serious complication. Old age people and the patients with co-morbid conditions like hypertension, Diabetes and COPD, are more susceptible to severe Covid-19 disease. Aims: The aim of the present study was to find the association between inflammatory biomarker and other parameters with severity of the covid-19 disease. Material and Method: This study was carried out in the Department of Biochemistry, Muzaffarnagar Medical College and Associated Hospital from April 2021 to June 2021. Biochemical parameters IL-6, Ferritin, D-dimer, CRP, and LDH were estimated by fully auto analyzer (AU-480 & Acces-2 chemistry analyzer). Hematological parameters were measured by cell counter (NIHON KOHDEN). Results: In this study, the biochemical biomarkers like IL-6, Ferritin, CRP, D-dimer and LDH were elevated in Covid-19 patients and the increase in these parameters were more in severe patients as compared to non-severe patients. Conclusion: In conclusion, the inflammatory parameters can be used as laboratory biomarkers and could help to the clinician/physician to rapidly identify the severity of Covid-19 disease.