Diabetic nephropathy is the major cause for chronic renal failure (CRF) and proteinuria is an independent risk factor for end stage renal disease. Hence, early identification and quantification of proteinuria is of prime importance in the diagnosis and management.Introduction:Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels.Material and methods:This study will be conducted in department of Biochemistry, Rama Medical College Hospital &Research Centre Kanpur. Study taken from IPD& OPD of medicine and department of Biochemistry Lab Rama Medical College Hospital.Results:All parameters- glucose p-value =0.0001, micropretein p-value =less than 0.001, protein p-value=0.001, creatinine p-value=0.005, albumin p-value=0.21, totel protein p-value equal 0.05 Between case study /case control p-value is Statistical significant. Conclusions:Purpose of This Study Is To Examine Relationship Between Protein Creatinine Ratio And Microprotein, Compare The Diagnostic Performance In Order To Investigate And Identify Relation Between Them In Type-2 Diabetes Mellitus (DM). The Random Urine P:C Ratio Predicts The Amount Of 24-Hour Urinary Protein Excretion With High Accuracy. Hence It Can Be Used As A Faster Diagnostic Substitute For 24-Hour Urinary Protein Estimation.