Introduction: Pregnancy-induced hypertension is one of the familiar medical problems faced during pregnancy. ] Approximately 13% of women with elevated maternal serum α-fetoprotein (MSAFP) developed PE compared with 1% of the women with normal MSAFP. The aim of study is to estimate Serum alpha feto protein in early second trimester as predictors of pregnancy induced hypertension. Method: A cross sectional study was conducted among the pregnant females who were in their second trimester attending the OPD clinic in Department of Obstetrics & Gynaecology, JK hospital, LNMC & RC, Bhopal for a period from Jan 2019 to June 2020. About 150 pregnant women were included in study considering inclusion and exclusion criteria. Data collected and entered in excel sheet and was analysed in epiinfo software using appropriate software. Result: It was observed that maximum number of pregnant women was in the 26-30 years age group 52%.It was observed that maximum number were 17-18 weeks of gestation and maximum number were of Primigravida39.3%. It was also observed that Sensitivity of 80% and specificity of 85.45% and a positive predictive value of 66.6% and a negative predictive value of 92.1% Conclusion: The present study confirmed the value of second trimester maternal serum AFP levels as predictors of PIH. This study provides evidence that elevated second-trimester MS-AFP is associated with increased risk ofpregnancy induced hypertension.