Background: Blood stream infection (BSI) is a common bacterial illness of paediatric age group.Bacteremia remains one of the most significant causes of morbidity and mortality in pediatric patients. Delaying diagnosis and treatment of bacteremia mayresult increased childhood mortality. Aim: We wanted to study the microbial profile, clinical profile andrisk factors of bacterial infections in children. Methods: This hospital based cross-sectional, observational study was conducted in the department of Paediatrics in a tertiary hospital, Indore, India. Children upto 03 years of age admitted in the department were enrolled in our study. Blood culture was done for all the patients.We compared the risk factors, clinical features, laboratory data, microbiologic results, and final outcome for patients with bacteremia and without bacteremia Results: In the present study, out of 88 febrile children bacteremia was present in24 (27.3%) of cases. Staphylococcus aureus was the most common pathogen isolated (25%), followed by salmonella (16%). Most common risk factor were malnutrition (wasting/stunting), low socio-economic status, incomplete vaccination and past history of hospitalization. The most common presenting symptom was cough/cold, convulsion, restlessness, not accepting feed, increased respiratory rate and excessive crying. Death rate was 8.3% in bacteraemic children whereas zero death occurs in non bacteraemic patients Conclusions: Pediatric bacteremia remains a burdensome public health problem. Morbidity and mortality rates was higher in bacteraemic child as compared to non bacteraemic children