Background: The common mental disorders i.e., depression and anxiety, are now presenting as major global public health problems.Limited evidences are available regarding burden of overweight and obesity and its association with mental health and role of intervention programmes in well being among children and adolescents in Indian scenario. Psychosocial factors work against the child with a weight problem and thus hamper his/her overall growth and development.Methodology: A systematic literature search was performed in PubMed, Embase, Google scholar, clinical trial.gov and Cochrane Library through March 2023 in the English language by two independent authors using a structured search strategy.Primary efficacy outcomes of the study were to find the the impact of obesity prevention interventions on the mental health and well-being of adolescents so that intervention strategies can be planned accordingly and intervention programmes can be given importance accordingly.Results: Total number of obese adolescents analysed in the present study are 6469 aged 11-18 years. The family communication and function, as well body image satisfaction indirectly affected psychological well-being through selfesteem and depression. The physical exercise, improvements in diet quality were mirrored by improvements in mental health over the follow-up period, while deteriorating diet quality was associated with poorer psychological functioning. The effectiveness of a community-based obesity prevention intervention designed to prevent obesity with a dual specific mental wellbeing objective in improving depressive symptomatology. Conclusion: The present study found that there is scarcity of research that reports impact of intervention programs on mental health among adolescents. In addition of assessing youth overweight status, mental health related problems must be addressed. it is pivotal to understand the range of individual, social and environmental mechanisms leading to obesity and mental illness, and help identify policies, interventions and strategies that will change the future trajectory and ‘disease burden’ in our country.