Objective: To evaluate the efficacy of parenteral amino acid supplementation in the management of diabetic foot ulcers. Methods: This case-control study was conducted at the Department of Surgery, Muzaffarnagar Medical College and Hospital, between October 2018 and February 2020. A total of 60 adult patients with type 2 diabetes mellitus and foot ulcers were randomized into two groups: Group A (n=30) received standard treatment while maintaining their regular diet, and Group B (n=30) received additional 200ml parenteral amino acids on alternate days for 15 days along with standard treatment. Patients were assessed for serum albumin, lipid profile, hemoglobin, creatinine, and uric acid levels. Wound healing was evaluated using Southampton and Asepsis Wound Scoring Systems on days 0, 5, 10, and 15. Results: Both groups were comparable in baseline characteristics including age, gender distribution, duration of diabetes, HbA1c levels, and biochemical parameters. Group B showed a significant increase in serum albumin levels (from 3.44g/dl to 4.63g/dl, p<0.01) compared to Group A (3.46g/dl to 3.3g/dl). While both groups showed improvement in wound healing, Group B demonstrated significantly better outcomes with 66.67% patients achieving normal healing according to Southampton Scoring System compared to 26.67% in Group A (p<0.05). Similarly, satisfactory healing by Asepsis Wound Scoring System was observed in 66.67% of Group B patients versus 23.33% in Group A (p<0.05). No severe wound infections were reported in Group B by the end of the study. Conclusion: Parenteral amino acid supplementation significantly improves serum albumin levels and enhances wound healing in patients with diabetic foot ulcers. This nutritional intervention should be considered as an adjunct to standard care for better management of diabetic foot ulcers.