Introduction: The ultrasound guided supraclavicular brachial plexus block and ultrasound guided Interscalene brachial plexus block both are used for surgery around shoulder joint. Supraclavicular block has proved to provide the same effect as with interscalene block. Ultrasound guided supraclavicular block has lower incidence of hoarseness of voice or horner`s syndrome. The ultrasound guided interscalene brachial plexus block is seems to be a standard technique for surgery around shoulder joint. However, the interscalene block may cause unilateral diaphragmatic paralysis. If compared to interscalene block, supraclavicular block can provide effective anaesthesia for surgery around shoulder joint, with less side-effects. Thus, we decided to perform a randomized double blind study to compare ultrasound guided supraclavicular brachial plexus block with interscalene brachial plexus block. Aims and objectives: In current randomized double blind study we compared ultrasound guided interscalene block and ultrasound guided supraclavicular block for surgery around shoulder joint. Methods and materials: In this prospective randomized double blind comparative study, we enrolled 60 ASA grade 1 or 2 patients who were posted for elective or emergency surgeries around shoulder joint under ultrasound guided brachial plexus block into one of the two groups, as shown in computer generated random number table. Group A patients were given ultrasound guided interscalene brachial plexus block and group B patients were given ultrasound guided supraclavicular brachial plexus block. Result: No significant difference was noted in demographic parameters between the groups. Time required for performing block was longer in group B when compared to group A which was statistically significant. Incidence of horner’s syndrome, phrenic nerve palsy and hoarseness of voice were high in group A when compared to group B which was also statistically significant. Conclusion: If summarized, ultrasound guided supraclavicular brachial plexus block is a very effective technique for surgery around shoulder joint with lower incidence of complications. Thus, ultrasound guided supraclavicular brachial plexus block can be used as an alternative method for surgery around shoulder joint.