Aim: The aim of the present study was to evaluate the efficacy of PRP treatment for tendinopathy. Methods: The present study was conducted in the Department of Orthopedics and the study used the data for specific methodological purposes, inclusion and exclusion criteria, clinical and ultrasound evaluation, PRP preparation procedure and treatment schedules and 100 patients were included in the study. Results: 100 patients suffering from mid-portion tendonitis submitted to PRP therapy were included in the study. There were 52 male and 48 females in the study. 85% patients had no habit of smoking and 25% had metabolic disorders. The individual basal values of VISA-A scores were widely scattered, so showing that subjects with different degrees of impairment were included in the trial. At 3 and 6 months post-treatment, mean VISA-A score increased significantly (63.7 ± 13.8 at 3 months (p = 0.00001) and 67.2 ± 14.1 at 6 months (p = 0.00001)). A positive relationship between Likert score and VISA-A score at 6 months was present (r = 0.55). Different degrees of patient satisfaction were observed for similar increases of the score. Conclusion: Tendinopathy is a highly prevalent tendon disorder and plagues a range of individuals from the common person to elite athletes. It may cause extreme pain and affect tendon function, which can impair normal life activities. Because the mechanisms of tendinopathy are not completely understood, the current treatment options for this tendon disease remain largely palliative. PRP is a popular cell-free therapy that is used worldwide to treat tendinopathy.