Background: Laparoscopic cholecystectomy is a minimally invasive surgical procedure used to remove the gallbladder. The present study was conducted to assess role of drain after laparoscopic cholecystectomy for acute calculous cholecystitis. Materials & Methods: 48 cases of laparoscopic cholecystectomy of both genders after gallbladder removal with a containing bag, the patients, who had no serious intraoperative complications, such as significant biliary and/or vascular injury or bleeding (>100 mL), were randomly allocated to undergo the placement of a drain in the subhepatic space (group I) or a sham drain (group II). Results: Group I had 10 males and 14 females and group II had 12 males and 12 females. ASA grade I was seen in 8 in group I and 4 in group II, grade II in 12 in group I and 13 in group II, grade III was seen in 4 in group I and 7 in group II. The mean operative time was 94.2 minutes in group I and 92.6 minutes in group II. Postoperative hospital stay was 3.2 days and 4.7 days in group I and group II respectively. Abdominal pain scores after 24 hours was 4.3 and 3.5 and shoulder pain scores after 24 hours after operation was 1 and 0 in group I and group II respectively. Parenteral ketorolac consumed was 120.4 ml and 122.6 ml in group I and group II respectively. The difference was significant (P< 0.05). Conclusion: Using drain in patients undergoing laparoscopic cholecystectomy offered no additional benefit.