Background: Allergic diseases have dramatically increased in the last decades. The present study compared topical olopatadine (0.1%) and alcaftadine (0.25%) in cases of allergic conjunctivitis. Materials & Methods: 70 patients of allergic conjunctivitis of both genders were divided into 2 groups of 35 each. Group I patients were prescribed topical 0.1% Olopatadine eyedrops and group II patients were prescribed topical 0.25% Alcafatadine eyedrops. Grading was done where 0 indicates no itch and 3 indicating constant desire to itch. Ocular redness and discharge were scored using 5 point scale (0–4), foreign body sensation and watering were graded using the 4 point scale (0–3). In signs, upper tarsal papillae were graded using 4 point scale (0–3) with 0 indicating no papillae and 3 indicating predominance of giant papillae. Results: There were 20 males and 15 females in group I and 17 males and 18 females in group II. At 15 minutes, 1 day and 1 week, 1 patient in group I and 2 in group II, 9 in group I and 7 in group II and 25 in group I and 26 in II recovered from discharge. 8 patients in group I and 7 in group II, 12 in group I and 8 in group II and 15 in group I and 20 in group II recovered from redness. 2 patients in group I and 3 in group II, 20 in group I and 17 in group II and 13 in group I and 15 in group II recovered foreign body sensation. The difference was significant (P< 0.05). Conclusion: Both drugs olopatadine and alcaftadine found to be equally effective in cases of allergic conjunctivitis.