Aim: The aim of the present study was to compare efficacy of ultrasound guided Supraclavicular and Infraclavicular blocks for upper limb surgery using Ropivacaine 0.5%. Material and Methods: A Randomized Controlled Trial was conducted in Vivekananda Institute of Medical Sciences, Kolkatta in between July 2016 to June 2017. Total 120 patients were divided in two groups i.e., 60 patients in each group. Group S (n=60) –Ultrasound guided Supraclavicular brachial plexus block was performed with 0.5% Ropivacaine. Group I (n=60) - Ultrasound guided Infraclavicular brachial plexus block was performed with 0.5% Ropivacaine. Results: The t-test showed that there was no significant difference in mean Ages, Weight and Height of the patients of the two groups (p>0.05). There was no significant difference in mean heart rate of the patients of the two groups for different time intervals (p>0.05). The t-test showed that there was no significant difference in mean SPO2, Systolic and diastolic blood pressure of the patients of the two groups for different time intervals (p>0.05). Conclusion: We concluded that ultrasound guided infraclavicular block provides superior quality of sensory, motor block and less side effect whereas duration of sensory block, motor block and postoperative analgesia was greater in USG guided supraclavicular block.