Background: The present study was conducted for assessing the incidence of diabetes mellitus type II and prediabetes among hand nerves entrapment neuropathy patients. Materials & Methods: It was a cross-sectional study involving 100 patients who reported with numberless of single side or bilaterally and was suspected of Carpal tunnel syndrome (CTS). Written consent was obtained from all the patients after explaining in detail the entire research protocol. Complete medical history of all the patients was obtained. Anthropometric variables of all the patients were recorded separately. Blood samples were obtained from all the patients and HbA1c levels were recorded. Results: A total of 100 patients were enrolled. Mean age of the patients was 43.5 years. Out of 100 patients, 38 percent of the patients were pre-diabetic while 28 percent of the patients were diabetic. Conclusion: CTS is a commonly encountered entrapment neuropathy associated with DM. Hence; periodic screening of CTS patients for metabolic derangement should be done.