Introduction: Health is a complete Physical, mental and Social wellbeing of a person and not merely an absence of any disease or deformity” [1]. Communicable & non-communicable diseases/life style diseases are emerging very fast not only in India but also across the globe. There is strong evidence that physical inactivity plays a pivotal role in the development of several chronic diseases [2]. Objective: study to assess the Physical and Mental Performance in subjects doing Gym Exercise with Yoga and Meditation in Indore city. Methodology: A comparative cross-sectional study was conducted in the community of Indore. Total 100 subjects of both the gender were selected by Systematic random sampling method. They were administered semi-structured questionnaire based on Anthropometric measurement, Vital Parameter, Specific Instruments and charts were used, by using SPSS 25. Result: there is a significant difference in the Dominant Hand Grip Exercise of gym exercisers, & in the Video Reaction Time of gym exercisers, & in Dominant Hand Grip Exercise of yoga & meditation exercisers,& in the Non Dominant Hand Grip Exercise of yoga/meditation exercisers,& in Trail Making Test A of yoga & meditation exercisers,& Difference in the Audio Reaction Time of yoga & meditation exercisers,. There is not much difference in the physical performance of the subjects doing gym exercise with the subjects doing yoga & meditation, Video Reaction Time of yoga & meditation exercisers. Conclusion: There is no difference in the mental performance of the subjects doing gym exercise with doing yoga & meditation.