Background: Knee osteoarthritis (OA) affects millions of adults and is characterized by substantial pain, joint stiffness, and functional limitations. The present study was conducted to assess NSAIDS and opioids in pain reduction in knee osteoarthritis. Materials & Methods: 50 cases of knee osteoarthritis of both genders were divided into 2 groups of 25 each. Group I were given 200 mg celecoxib and group II were given 64 mg hydromorphone. Pain was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain subscale (0–100, 100-worst). Results: Group I had 15 males and 10 females and group II had 11 males and 14 females. The mean WOMAC score in group I was 50.2 and in group II was 64.3. The difference was significant (P< 0.05). Conclusion: NSAIDS found to be more effective than opioids in pain reduction in knee osteoarthritis.