Introduction:In India, SCD is distributed geographically in the central and western regions. It has been estimated that about 5200 live births have SCD every year. As per an Indian Council of Medical Research Survey (IJMRS), about 20% of children with SCD expired by age of two and 30% children with SCD among the tribal community died before they reach adulthoodGujarat with 89.12 lakh tribal population is expected to have at least 70,000 SCD patients. The dhodia, dubla, kukna, gamit, chaudhary, halpati, varli, kokani, kathodi, kolcha, kotwadia Due to improved survival and population movement, the global burden of SCD is increasing with the annul number of SCD new-born expected to increase from 3,00,000 to more than 4,00,000, between 2010 and 2050 Materials and Methods: This is a prospective single center hospital based cross sectional study. Thirty patients of known case of SCD patients who came in orthopedic OPD in New Civil Hospital, Surat between January 2019 and May 2020 included in the study. Results: Among the 30 patients enrolled, highest number of patients belonged to age group of 12–32 years (n=24) and while the lowest belonged to age group of <12 years. In the study, 17 patients were female and 13 patients were male. In this study, the number of patients (11/30) who were continue on therapy of hydroxyurea (HU) for at least one year were less as compared to their counterpart. In this study 6 (20%) patients had salmonella infection and rest of the patients had no active infection. Osteoarticularmanifestation was found in different bones among which hip joint was involved in highest number of patients (n= 16) followed by joint pain (n=8), tibia (n= 3), radius (n= 2), and femur (n=1). In this study, 19 patients were observed to have involvement at the epiphysis region whereas 3 patients had involvement at metaphysis region. In this study, 16 patients were found to have avascular necrosis (AVN) hip, 8 patients had joint pain, 3 patients had proximal tibia osteomyelitis. Conclusion: From this study it can be concluded that osteoarticular manifestation occurring in patients with SCD in where early radiological findings are not good but patients showing clinically good range of motion of joint and weight bearing capacity so we can avoid operative intervention. As sickle cell disease is genetic disorder so there is no definitive treatment of it. As infarction is the continuous process so life span of implants used in operative intervention is less. Best management of sickle cell disease is early diagnosis of disease and early evaluation and management of its complications.