Background: World Health Organization (WHO) has defined Adverse Drug Reaction (ADR) as a response to a drug that is noxious and unintended, and which occurs at doses normally used in man for prophylaxis, diagnosis or therapy of disease or for the modification of physiological function. ADR has a major impact on the cost of afflicted person, it causes around 0.2 – 24 % hospital admission as per previous report.But there are limited studies conducted on medical students, so, we conducted this study to assess knowledge, attitude and practice about Adverse Drug Reactions and Pharmacovigilance among medical undergraduates.Methods: This cross-sectional study was conducted among 400 MBBS students (both male and female) under the department of Pharmacology, Government Medical College, for a duration of 3 months. The self-filled questionnaire comprised of four main domains, i.e., demographic characteristics, knowledge, attitude and practice about ADR and PV including an introduction section which covered the details about objective and rationale for the study. The collected data was entered in the MS excel sheet. Chi-square analysis done to find association between the dependent and independent variables and a p value of <0.05 was considered to be statistically significant. Results: In our study, a total of 400 MBBS students (both male and female) were sent the google forms as questionnaire and 376 students responded back to the questionnaire. When students were asked, whether they are aware of Adverse Drug Reactions (ADR), 99.7% of students responded they were aware of it, but when asked to define the ADR, only 66.2% of students were able to correctly define it. Similarly, when students were asked, whether they are aware of the difference between ADR and Adverse Drug Events (ADE), 94.9% of students responded they were aware of it, but when asked to define the ADE, only 54.8% of students were able to correctly define it. When students were assessed for the practice of Adverse Drug Reactions and Pharmacovigilance, 28.1% of students disagreed with the fact that they never experienced ADR in life, but 42.4% of students agreed with on that they have noticed patient with any of the ADRs. Only 27.2% strongly agreed with the fact that they were trained in ADR reporting with ADR form.Conclusion: Themedical undergraduate possess adequate knowledgewith declinein attitude and practice of pharmacovigilance & ADR reporting. There should be regular awareness training program for students & regular workshops for healthcare professionals. The conclusion of the study is that medical students, who will become future healthcare providers, should be trained well right from undergraduate period. So students should realize the importance of reporting ADR in future for the welfare of the community.