Introduction: Cardiovascular disease (CVD) is a common and complex disease, especially in middleaged people those over 50 years old. The aim of this study was to compare the plasma levels of the established risk markers for atherosclerosis (such as lipoproteins, C-reactive protein and fibrinogen) in patients with periodontal disease and healthy patients.Materials & Methods: The study population included total of 50 patients. The populations were divided into two groups. The group A periodontitis consists of 25 patients and the second group B non periodontitis group consist of 25 patients. All patients underwent a comprehensive periodontal examination, including radiographs and clinical examination.Results: In agreement with other studies, we found significant differences in total cholesterol and LDL levels between periodontitis and non-periodontitis cases, which may account for the correlation between periodontal and cardiovascular diseases, to which high cholesterol and LDL levels are known risk factors. Discussion: The inϐlammation of periodontium is caused by bacteria, primarily by gram negative anaerobic bacteria. The link between periodontal disease and cardiovascular health is strong, and it's clear that the two are intertwined. Researchers discovered that the bacteria causing disease can spread throughout the blood via blood stream producing inϐlammation in heart vessels and infection in heart valves.