Aim: To assess the prevalence and severity of periodontal disease in patients diagnosed with oral potentially malignant disorders (OPMDs) and analyze its association with specific OPMD subtypes. Material and Methods: A cross-sectional observational study was conducted on 100 patients clinically and histologically diagnosed with OPMDs. Patients aged 18 years and above with no recent periodontal treatment were included. Comprehensive periodontal examinations were performed, recording Plaque Index (PI), Gingival Index (GI), Probing Pocket Depth (PPD), and Clinical Attachment Loss (CAL). The severity of periodontal disease was graded using the 2017 World Workshop Classification. Results: The mean age of participants was 45.6 ± 12.8 years, with 65% males and 35% females. The OPMD subtypes included leukoplakia (45%), oral submucous fibrosis (40%), and erythroplakia (15%). Erythroplakia exhibited the highest periodontal severity, with mean PI, GI, PPD, and CAL values significantly higher compared to other subtypes (p < 0.05). Regression analysis revealed a significant association between OPMD subtypes and periodontal parameters, with erythroplakia showing the strongest correlation. Periodontal disease severity was higher in females, with significantly greater GI and CAL values (p < 0.05). Conclusion: This study demonstrates a significant relationship between periodontal disease and OPMDs, particularly in erythroplakia and oral submucous fibrosis. The findings emphasize the importance of early identification and integrated management of periodontal health in patients with OPMDs to reduce the inflammatory burden and potentially mitigate the risk of malignant transformation.