Background: Intussusception in adults is a rare condition that presents as a medical emergency. It is caused by the invagination of one bowel segment into another, which further leads to obstruction, ischemia, and perforation. Very often, it presents as a diagnostic and therapeutic challenge. Intussusception in adults needs thorough evaluation due to its vague presentation. It is usually associated with underlying pathology. We present a case of intussusception in a 67-year-old female with intestinal lipoma at the lead point in association with mucinous adenocarcinoma and tubular adenoma. It is unusual for distinct intestinal pathologies to co-exist. Therefore, dealing with such cases requires high suspicion of associated pathologies for proper, complete diagnosis and treatment.