Background: Lymphadenopathy is a frequent occurrence in therapeutic settings. It might be challenging to diagnose swollen lymph nodes solely by clinical judgment because the clinical signs of lymphadenopathy often resemble those of other disorders. The present study was conducted to assess diagnostic utility of fine needle aspiration cytology in lymphadenopathy. Materials & Methods: 232 patients of lymphadenopathy of both genders were selected. FNAC was administered to the patients using a Franzens handle, a 10 ml syringe, and a 23–25 G needle. The histological diagnosis derived from sections stained with H&E was further correlated and compared with the FNAC diagnosis in the instances that were available. Results: The type of lesion was CNSL in 53, TBLN in 114, ANSL in 25, NTGL in 17, metastasis in 21, leukemia in 19 and lymphoma in 2 cases. Common site was cervical in 97, submandibular in 70, axillary in 23, inguinal in 12, generalized in 25 and others in 5 patients. The difference was significant (P< 0.05). Sensitivity and specificity of tuberculous granulomatous lymphadenitis was 85.2%and 97.8%, chronic non-specific lymphadenitis was 84.1% and 93.75%, non- tuberculous granulomatous lymphadenitis was 82.3% and 99.5%, metastasis was 95.3% and 96.4%, Hodgkins lymphoma was 100% and 100%, Non- Hodgkins lymphoma was 98.5% and 100% and leukemia was 100% and 100% respectively. The difference was significant (P< 0.05). Conclusion: Particularly in facilities without access to sophisticated diagnostic methods, FNAC is an easy, safe, self-reliant, economical, and time-efficient outpatient procedure. It can be applied to lymphadenopathies as a preliminary diagnostic method.