Aim: The study aimed to evaluate the effects of a single dose of dexmedetomidine administered prior to extubation-on-extubation conditions, hemodynamic stability, and post-operative outcomes in adult patients following general anesthesia. Materials and Methods: This prospective, randomized study included 100 adult patients aged 18-85 years undergoing elective surgeries under general anesthesia. Patients were randomly assigned to either Group A (dexmedetomidine 0.75 µg/kg, n=50) or Group B (normal saline, n=50). Both groups were premedicated with midazolam and glycopyrrolate. Following standard anesthesia induction with propofol and fentanyl, intubation was performed after 3 minutes of mask ventilation with atracurium. Dexmedetomidine or saline was administered 30 minutes before the end of surgery, and extubation conditions were evaluated. Hemodynamic parameters, including mean arterial pressure (MAP) and heart rate (HR), were recorded at various time points. Post-extubation cough, sedation, shivering, post-operative nausea and vomiting (PONV), and other complications were also assessed. Results: Group A had 64% of patients with no post-extubation cough compared to 60% in Group B (p = 0.95). MAP was significantly higher in Group B at the 3-minute post-surgery mark (98.45 mmHg vs. 88.85 mmHg, p = 0.03). Group A had a significantly lower heart rate at T0 and 3 minutes post-administration (69.35 bpm and 71.50 bpm, respectively), compared to Group B (75.65 bpm and 82.90 bpm, p = 0.03, 0.02). Group A also had lower rates of severe PONV (14% vs. 52%, p = 0.02) and a lower incidence of shivering (10% vs. 30%, p = 0.05). Sedation scores were comparable between the groups. Conclusion: A single dose of dexmedetomidine administered prior to extubation improves extubation conditions, enhances hemodynamic stability, and reduces post-operative cough, shivering, and PONV. Dexmedetomidine is effective in managing post-operative recovery, though careful monitoring is required to manage potential side effects like bradycardia.