Background: Vitiligo is common depigmentary disorder characterised by milky white maculae’s and patches. It has a incidence of 3-4% in India with equal predisposition in both the sexes. Aims/ objectives: 1. To compare efficacy and safety of microneedling followed by methotrexate 1% gel versus microneedling followed by tacrolimus solution (0.1%) in localised stable vitiligo. Method: 40 patients of stable vitiligo of age 15 to 45 years were enrolled from the skin OPD. They were randomly divided into 2 groups of 20 each. Microneedling was done and followed by application of methotrexate 1% gel in group A and Tacrolimus ointment 0.1% in group B. Then the patients were advised to apply the agent twice daily. This procedure was repeated at 3 weekly intervals till 24 weeks. All the patients were evaluated for therapeutic outcome both objectively by Vitiligo Area Severity Index(VASI) and photographically every 3 weeks till end of 36 weeks. The result was tabulated with respect to percentage of improvement in VASI score (grading will be done from 0-4) and impact on the DLQI. Result: At 36 weeks follow-up, in group A very good , good, moderate , mild and no improvement was seen in 10%,15%,50%, 25% and 0 respectively whereas in group B it was 0, 15%, 45%, 25% and 15% respectively. Mean percentage of reduction in DLQI in group A and group B was 50.5% and 48.9% respectively. Conclusion: Significantly better outcome was observed in group A in comparison to subjects of group B. Incidence of erythema and burning sensation was significantly higher among subjects of group B.