Introduction: Acute pancreatitis (AP) is a sudden inflammation of the pancreas that can range from mild discomfort to a life-threatening condition. Objective: The basic aim of the study is to find the comparison between omega 3 fatty acid infusion versus octreotide infusion in acute pancreatitis. Methodology of the study: This comparative study was conducted and data were collected from 220 patients suffering from acute pancreatitis.Patients in group A were receive a daily infusion of omega-3 fatty acids (EPA and DHA) at a dose of 1.5 g/kg body weight.The infusion was administered intravenously over a period of 4 hours for 7 consecutive days or until discharge, whichever comes first. Patients in group B were receive a daily infusion of omega-3 fatty acids (EPA and DHA) at a dose of 1.5 g/kg body weight.Results: A total of 220 patients were enrolled in the study, with 110 patients randomly assigned to the omega-3 fatty acid infusion group and 110 patients assigned to the octreotide infusion group. At baseline, CRP levels were comparable between the two groups (150.4 ± 35.2 mg/L vs. 148.6 ± 34.8 mg/L, p=0.72). By Day 3, the omega-3 group showed a greater reduction in CRP levels (95.8 ± 28.4 mg/L) compared to the octreotide group (112.6 ± 30.1 mg/L), with a statistically significant difference (p<0.01).Conclusion:It is concluded that omega-3 fatty acid infusion is superior to octreotide infusion in the management of acute pancreatitis. Omega-3 fatty acids significantly reduce inflammation, shorten hospital stays, and lower the incidence of complications.